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ERK1/2 may be activated as a consequence of aberrant activation of upstream signaling molecules or during development of drug resistance following treatment with kinase inhibitors such as those for PI3K or BRAF.
Long-term, but not acute, loss of Cdk5 led to decreased p25 levels, suggesting that Cdk5/p25 may be activated as a homeostatic mechanism to attenuate epileptiform activity.
This analysis suggests that Francisella may not significantly impact the activity of the main transcription factors known to be activated as a result of TLR4 engagement and subsequent signaling cascade.
To further demonstrate the therapeutic potential of zinc finger technology, we designed synthetic zinc finger transcriptional activators targeted to the promoter of the γ-globin gene, which can be activated as a therapeutic approach to sickle cell disease and β-thalassemia.
However, it can also be activated as a second screen companion to the main action.
Girardi said it was possible Posada could be activated as a designated hitter while his arm recovers, but he seemed leery of that.
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While autophagy probably could be activated as an adaptive response to avoid cell death, this process also appears to be conjunctly activated with apoptosis.
This suggests that bone turnover is activated as soon as a minimal mineral loss has occurred.
So, in contrast to cyclophosphamide where 90% of a dose is activated, as much as 70% of a dose of IFO may be eliminated by inactivating pathways.
Mr. Drum and his colleagues have found that the edema factor, which is harmless while inside the bacterium, is activated as soon as it bumps into a common component of cells known as calmodulin.
Accumulating data suggest that autophagy is activated as a compensatory mechanism upon proteasome activity is impaired.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com