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Although no correlation between Vpr functionality of dominant primary alleles and evolution of viral load during HIV-1 infection could be made from two unique patients, this could be achieved through large scale longitudinal studies investigating molecular and functional aspects of HIV-1 Vpr.
This can only be achieved through large federated pools of information that include patient genomic data and their health histories.
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Discriminating between passengers and drivers within a genomic region may therefore only be achieved through large-scale functional analyses and combinatorial approaches examining many genes in concert.
Volume resuscitation in TCA should ideally be achieved through large-bore peripheral intravenous access above the diaphragm.
This has been achieved through large-scale and incremental interventions into the built environment, including the construction of an international port; large-scale migration from rural areas and other cities; and urban sprawl, accompanied with the emergence of new housing forms.
Improved power to detect these effects has been achieved through larger sample sizes and meta-analysis, dense genotyping (for example in Metabochip fine-mapping regions) and imputation up to targeted genomic sequences and 1000 Genomes Project Consortium reference panels.
Evidence suggested any significant decline in cattle TB "could only be achieved through such large scale and draconian measures to reduce badger numbers as to make the option impractical, unaffordable and publicly unacceptable".
This target will be achieved through the large penetration of RES technologies in electricity production, heat supply, and in the transport sector.
We focus principally on wind and PV developments since they can be achieved through both large- and small-scale activities, which are important for increasing the resilience of the energy supply in a given region or locality.
The diversity and complexity of data will be invaluable to the greater research community, and could only be achieved through such a large-scale project.
The resurgence of the disease and recent developments using a single dose of oral azithromycin have renewed optimism that eradication can be achieved through a comprehensive large-scale treatment strategy.
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