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Transcript-level regulation may also be achieved through epigenetic modification, such as CpG island methylation, which inhibits transcription either at the promoter region or downstream [ 10, 11].
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Epigenetic alterations in gene expression may be achieved through changes in the tertiary structure of a DNA strand.
This could be achieved through different fronts.
This is achieved through transcriptional and epigenetic regulation, that will integrate also the cell response to the extrinsic environment.
These alterations are achieved through the recruitment of various epigenetic-modifying factors, like histone deacetylase complexes such as SMRT (Lin et al, 1998) and N-CoR (Grignani et al, 1998), and DNA methyltransferases (Di Croce et al, 2002).
This epigenetic control is achieved through DNA methylation, histone modification, and chromatin remodeling [45], [46].
This suggests that control of gene expression is achieved through multiple mechanisms which include MAR attachment and histone modifications and other epigenetic marks (Linnemann & Krawetz 2009b).
Epigenetic silencing may therefore better be defined as an epigenetic regulation that maintains a functionally silent state, irrespective of whether it is achieved through a transcription-independent (TGS) or transcription-dependent (PTGS) activity, or a combination of both.
But that was achieved through air munitions.
Balancing was achieved through oversampling.
Consensus was achieved through discussion.
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