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Here again, miR-34 shows the advantage of its multi-target potential, as both stem cell genes Notch and Bcl-2 are inhibited by miR-34 at the same time, a potent synergy may be achieved in blocking both Notch signalling pathway and the anti-apoptotic function of Bcl-2 in tumor-initiating cells or cancer stem cells.
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Similarly, a restoration of HBV- and HCV-specific CD8+ T cells isolated from chronically HBV or HCV-infected patients, respectively, could be achieved in vitro by blocking PD-1/PD-L1 interaction.
In certain traffic scenarios, we observe up to a 68% of the ideal performance gain that could be achieved in HoL-blocking and buffer-hogging prevention.
Finally, significantly higher ionic conductivities can be achieved in a block copolymer/IL solid-state film compared to a homopolymer/IL film at the same IL content (wt%), because the non-conductive microdomain excludes IL, which produces a higher local IL concentration in the conductive phase.
In this study, forearm blood flow/venous plethysmography was used to show that SPAG levels could be achieved in patients, which blocked substance P-induced vasodilation.
This might be achieved in the clinic by blocking the T-cell costimulation using CTLA-4Ig, a fusion protein consisting of the extracellular domain of CTLA-4 linked to the constant region of IgG1.
Medical control of hypercortisolemia can be achieved in two ways: either by blocking cortisol production to achieve normal levels, or by blocking cortisol secretion completely along with glucocorticoid replacement (block and replace).
Making up our half an hour of not being sedentary does take an effort, but at least it can be achieved in manageable 10-minute blocks, can be made part of life without having to find fresh hours in the day – and above all has the merit of being in our control.
This could be achieved in a 30 minute block or in shorter bouts of walking of 10-15 minutes.
For short block lengths, it is shown that near-ML performance can indeed be achieved in many cases.
This will be achieved in three ways.
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