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Volume support should be limited to 10 20 ml/kg of isotonic saline administration and, if sustained normalization of the blood pressure cannot be achieved, early initiation of cardiovascular pharmacological support is recommended.
This supports the concept that optimal circulatory support in sepsis should be achieved early.
Another approach to consider for future trials is to incorporate an intermittent dose-intense temozolomide and HCQ regimen (as used in Rangwala et al., this issue ) in combination with brain radiation so that higher doses of HCQ might be achieved early in the course of GB therapy.
Their findings confirmed further that when therapy is aimed at improving oxygen delivery (especially in the severely ill, in whom control group mortality was greater than 20%), goals must be achieved early, before the development of organ failure, if significant improvements in outcome are to be achieved.
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†Mortality from smoking can cause point prevalence to fall; hence prevalence target can be achieved earlier in the smoking model.
Obviously this may be achieved earlier or later, depending on Malawian staff already in place and the number of postgraduate trainees joining the COM.
Further (explorative) questions include whether remission will be achieved earlier and by more patients during inpatient therapy because of the web-based preparatory intervention.
We found that higher plant species diversity was achieved early and was sustained in planted versus unplanted wetlands.
The logic of the BCG matrix thinking is the following: "The payoff for leadership is very high indeed if it is achieved early and maintained until growth slows.
As can be seen, a rapid COD removal was achieved early on so that more than 60%% of COD removal occurred within the first 20 min.
The payoff for leadership is very high indeed if it is achieved early and maintained until growth slows.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com