(3) In addition to the diversity of interaction interfaces, the specificity and selectivity of CaM target activation may be achieved by variations in the target-specific dissociation and cooperatively effected dissociation constants, the order of Ca2+-CaM-target complex assembly and the number of Ca2+ ions required to bind CaM for target activation.
Further electronic tuning has been achieved by variation of the appended donor (N,N-dimethylamino and methoxy groups).
Distinct changes in film morphology, from continuous surface coating to open porous format, were achieved by variation of processing parameters such as collagen:PCL ratio and the weight of the starting lyophilised collagen mat.
Particle diameters between 3 and 17 nm and saturation magnetizations from 26 to 89 Am2 kg−1 were achieved by variation of iron salt concentration, reaction temperature, ratio of hydroxide ions to iron ions and ratio of Fe3+/Fe2+.
Instead, this is achieved by variation in the spacing between the half-sites (Marmorstein et al, 1992), as specified by the linker section of the protein (Reece & Ptashne, 1993).
This flexibility is achieved by variations in actin polymerization speed.
Surgery is, unfortunately, also a major source of avoidable morbidity and mortality worldwide, 1 2 though substantial improvements can be achieved by reducing variation in the reliability of surgical care processes.
A further improvement in the semantic interpretation and consistency of discovered topics might be achieved by exploring variations of topic models that consider word bigrams – the reoccurrence of e.g. the bigram "biodiversity loss" allows a more conclusive interpretation of a topic than the individual occurrence of the two words "biodiversity" and "loss".
Rational tailoring of the absorption characteristics can be achieved by NW geometry variation.
This activity is even more crucial in software product line (SPL) development, since it is also necessary to identify whether the NFRs of a particular product can be achieved by exercising the variation mechanisms provided by the product line architecture or whether additional transformations are required.
