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We have demonstrated that manipulation of cofactors can be achieved by external and genetic means and these manipulations have the potential to be used as an additional tool to achieve desired metabolic goals.
Cell fate reprogramming, such as the generation of insulin-producing β cells from other pancreas cells, can be achieved by external modulation of key transcription factors.
The restriction of molecular motion or switching between bistable conformations can be achieved by external stimuli such as ion or organic molecule binding, pH change, or by photoisomerization of the molecule.
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The model block size was 2000 (W) × 2000 (H) × 650 (T) (mm × mm × mm) and the ground stress field was achieved by external compensation method, the maximum output horizontal and vertical direction of cylinders were 3000 kN, and the maximum load intensity was 2.23 MPa.
Their conditional immortalization was achieved by external stimulation with analogs of physiological ligands.
Activation of TRPM8 currents was achieved by external application of 20 μM Icilin.
Quantification was achieved by external calibration versus matrix-matched standards (BCR-144R and CRM029-050) and standard addition with aqueous standards.
We showed that height catch-up, of a magnitude much greater than that which has been achieved by external nutritional interventions within the −9 to 24 mo window, frequently occurs between 24 mo and adulthood, even in the absence of nutritional supplementation.
Currently such isolation can only be achieved by using external components, adding bulk and cost to designs.
Trivially, this might be achieved by the external addition of more starting materials, but a more advanced system could regenerate precursors internally in a form of metabolism.
The break of reciprocity in LTI elastodynamics is only possible through the break of time reversal symmetry on the micro-level, and this can be achieved by imposing external biases, adding nonlinearities or allowing for time-varying system properties.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com