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Knowledge of the mechanism of cancer initiation by estrogens suggests that prevention of cancer can be achieved by blocking formation of the depurinating estrogen-DNA adducts.
In tumors with wild type p53, activation of p53 to induce apoptosis can be achieved by blocking Mdm2 or Mdm4 binding to p53 (Martins et al., 2006; Shchors et al., 2013; Ventura et al., 2007; Wang et al., 2011; Xue et al., 2007).
Reversal and modification of the tumor suppressor epigenetic state can be achieved by blocking DNA and histone methyltransferases as well as histone deacetylases with different doses of ATFs and chromatin remodeling drugs: the methyltransferase inhibitor 5-aza-2'-deoxycytidine and the histone deacetylase inhibitor suberoylanilide hydroxamic acid.
Inhibition of this process can be achieved by blocking any of these stages [3].
However, at least in mice, the increase in muscle mass that can be achieved by blocking myostatin activity after muscle development is only about one-fourth to one-third of the increase in muscle mass caused by constitutive myostatin deficiency [9] [12].
Lowering of blood cholesterol levels can be achieved by blocking either of the two pathways.
Similar(41)
The anti-inflammatory effects are achieved by blocking the activation of NF-κB, secreting anti-inflammatory cytokines, and inhibiting the release of pro-inflammatory cytokines, such as TNF-α and IL-6 (Tilg and Moschen, 2006).
High specificity and sensitivity for the mutant C allele were achieved by blocking non-specific amplification of the wild type allele with an amine blocked T specific primer.
Synaptic isolation of jcBNST neurons was achieved by blocking glutamate and GABA receptors using 10 µM 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), 50 µM AP-5 and 30 µM bicuculline in the bath.
Pain reduction is achieved by blocking nerve fibres.
This is achieved by blocking MAPKs and NF-κB activation in human chondrocytes.
More suggestions(15)
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be achieved by separating
be achieved by decreasing
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be prevented by blocking
be attenuated by blocking
be boosted by blocking
be won by blocking
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be achieved by keeping
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com