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Although between-centre heterogeneity can be accounted for, statistical techniques are evolving and imperfect [ 1].
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A commonality among these studies is that genetic links exist between genotyped subjects and these must be accounted for in statistical analyses.
Resilience levels related to individual mental disorders varied between the two study phases in ways which would not be accounted for by statistical power (since associations tended to be stronger, if anything, in the smaller follow-up sample).
In clinical trials involving heterogeneous patient samples with respect to the status of AChEI drugs, the effects of AChEI drugs should be accounted for during statistical analysis to isolate and accurately evaluate the effects of investigative treatments.
In these cases, the block effect must also be accounted for in a statistical model.
Sequence similarity of probes to non-target sequences below this threshold was allowed, but could be accounted for using the statistical algorithm described below.
This can either be accounted for by applying statistical correction methods (e.g. Bonferoni) or by investigating at least two different populations.
The choice of applying several randomized trials in the same cohort carries the risk of interaction between treatments that must be accounted for in the statistical analyses.
Non-response and drop out will primarily be accounted for by calculating statistical weights, or by conducting complete case analysis under the missing at random assumption, as appropriate.
For the comparison between ETV and shunting, important confounders, like age and origin of hydrocephalus need to be accounted for with sophisticated statistical methods [ 24], although this still falls short of the gold-standard of randomization.
The analyses of rehabilitation outcomes were based on the 50 intervention participants and 105 control participants who completed 4-month follow-up, as dropout at 1 year could be accounted for by the statistical model.
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