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Cartilage defects are often found to be accompanied by defects of the subchondral bone.
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To determine if the defects in O-glycan secretion are accompanied by defects in luminal extracellular matrix assembly, we analysed the SGs of γCOP mutant embryos by TEM.
The reduced capacity of DHA-treated, IFNγ-activated macrophages to control the infection was accompanied by defects on proinflammatory cytokine production, phagolysosome maturation, and oxidative burst.
Salivary gland invagination and migration defects in gyc76C mutant embryos were accompanied by defects in lumen shape.
Multiple myeloma (MM) is an immunoproliferative disease that is characterised by the uncontrolled proliferation of plasma cells, which is accompanied by defects in the immune system.
Multiple myeloma (MM) is an immunoproliferative disease characterised by the uncontrolled proliferation of plasma cells, which is accompanied by defects in the immune system.
Recent work published by our group found that the prolonged lag phase is accompanied by defects in mitochondrial distribution and inheritance associated with increased mitochondrial oxidation [ 38].
This results in increased and uncoordinated contractions of the cells, and is accompanied by defects in cell-cell adhesion that ultimately cause the amnioserosa to lose integrity.
This collapse of the lysosomal tubular network is accompanied by defects in autophagosome-lysosome fusion and the accumulation of lipofuscin within lysosomes.
Taken together, these results show that the DC phenotype in foscrb Y10A embryos is accompanied by defects in the establishment of the complex actomyosin apparatus at the LE of the DME cells and by the disturbance or even loss of different components of the ZA (schematised in Figure 2M,N).
This defect is accompanied by defective SC maturation including signs of nuclear immaturity, a failure of the nuclei to descend to the base of the tubules and disturbed development of the cytoskeleton.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com