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A possible explanation for the reduced activity of 52 compared to 7 and 38, and the lack of detectable activity of 51, could be that this non-planar conformation cannot be accommodated upon binding to the CB2R.
The two carbons at the base of the cyclopropyl ring can either be oriented above or below the plane of the tricycle, and thus a possible explanation for the moderate CB2R agonist activity of 53 is that one of these conformers can be accommodated upon binding to the receptor.
Similar(57)
(Larger groups can be accommodated).
Both tragedy and triumph must be accommodated.
It has interests that must be accommodated.
They should be accommodated into the system".
Other file types can also be accommodated.
Understudies, no matter decorated, cannot be accommodated.
Most combinations of subjects can be accommodated.
4) Be accommodating but not slavish.
Be accommodating.
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