Sentence examples for be accessible for binding from inspiring English sources

The immunogenic parts are often located on the surface of pathogenic proteins, because they have to be accessible for binding.

In brief, the cleavage site of a substrate for SOFA-HDV ribozyme should harbor a guanosine in position +1, no guanosine is position −1, should be in agreement with the previously determined preferable nucleotides in positions −1 to −2, and, as much as possible, should be accessible for binding.

Indeed, our analysis showed that there may be as many as ~46,000 HNF4α-Alu elements in DNase hypersensitive regions genome-wide, suggesting that they may be accessible for binding and therefore may affect transcription.

We wondered whether the histidine side chains of an SDS denatured protein, which are buried inside a mixed detegent-protein micelle, would be accessible for binding to Ni/NTA and whether thus detergent denatured proteins could be purfied by immobilized metal ion affinity chromatography (IMAC).

The authors of the original paper conclude that PIAS3, being unable to bind the mutated MITF, is accessible for binding and thus inhibition of STAT3.

Each histone consists mostly of a globular domain except for an N-terminal tail, which protrudes from the nucleosome where it is accessible for binding to DNA, for protein interactions, and for covalent attachment of small molecules.

Proteolysis is an excellent method to study protein flexibility and transient population of protein high energy states, as long as flexible or partially unfolded regions in the protein are accessible for binding and proteolytic cleavage [ 66].

Interestingly, at least two similar neutralizing Abs targeting the fusion peptide were generated from immunization of mice with recombinant H5N1 HA0 [ 126] or memory B cells of pdmH1N1 infected person [ 127], suggesting that this highly conserved liner peptide is at least partially exposed to induce Abs and is accessible for binding which warrants further investigation.

However, it is conceivable that this phenomenon may involve a cooperative effect with KDR, either via cross receptor signalling, or by PlGF displacement of VEGF already bound to Flt-1, thereby increasing the VEGF that is accessible for binding to KDR.

Thus, an auto-inhibited kinesin molecule would not be expected to be accessible for TRAK binding or available for transport, whereas binding to a TRAK adaptor would be expected to activate kinesin motility.

If PxAP9 should also prove to be catalytically ineffective, the active site will still be accessible for the binding of peptides that cannot undergo cleavage and so a role similar to the PAGs/Bla g2 in peptide binding might be feasible.