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Finally, NMD was found to be absolutely required for liver regeneration.
Among these mechanisms, only few have been found to be absolutely required for virulence in animal model systems.
This suggested that the HMG domain alone is capable of mediating self-association, though the HMG domain may not be absolutely required for this association.
Importantly, sustained transmembranous calcium flux, activation of Src-kinases as well as activation of PI3K were found to be absolutely required for CD28SA-mediated production of IFN-γ and IL-2.
Although phosphorylation of L-plastin does not appear to be absolutely required for its recruitment to actin polymerization sites, it might, by increasing the pool of high affinity L-plastin, contribute to the fine-tuning of actin turn-over.
This suggests that by the time we reach t = 3 BicD levels, we are observing minus-end directed transport on droplets that are functionally null for BicD, consistent with the idea that BicD may not be absolutely required for droplet motion.
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Position in latitude and longitude is absolutely required for geocasting.
Second, IN is absolutely required for viral replication and mutations in a number of key residues block the viral replication.
In prokaryotes, it is absolutely required for cell survival, thus representing an attractive target for the development of new broad-spectrum antibacteria inhibitors.
Since an intact gag-pol structure is absolutely required for retroviral DNA mobilization and RCR, the trans-lentiviral vector design significantly reduces this risk.
Because HIV-1 integrase is absolutely required for viral replication and because it has no cellular equivalent, this enzyme is an excellent target for a chemotherapeutic approach.
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