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Interestingly, omacetaxine mepesuccinate has shown notable activity against leukemic stem cells (LSCs) of CML origin with the agent having a similar inhibitory effect on BCR-ABL T315I-expressing LSCs in comparison to non-mutant BCR-ABL-expressing LSCs [ 82], indicating that the agent may be able to markedly inhibit clonal expansion in select CML patients.
Collectively, the rapid changes in biological and physicochemical attributes that we observed suggest that even relatively small forest fragments may be able to markedly influence impaired streams and that conservation and restoration of small, discontinuous forest fragments may be important for maintaining stream ecosystem integrity in agricultural landscapes.
It is important to point out that although the intensity of the incident light and the sensitivity of the CP-OCT detector can be increased in the future, improving these factors may not be able to markedly improve signal penetration, especially at intensity levels that are safe for diagnostic CP-OCT imaging.
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The results show that the proposed ML-based framework was able to markedly outperform state-of-the-art approaches.
All the tested dosages were able to markedly decrease food intake and body weight after a 9-day treatment.
On considering 1% fiber volume ratio and different strip geometries, we show that the analyzed reinforcing strips owe remarkable alkali resistance and are able to markedly improve the toughness of the base material.
As a class of cis-regulatory elements, enhancers were first identified as the genomic regions that are able to markedly increase the transcription of genes nearly 30 years ago.
The administration of diazepam (DZ) + pentobarbital (PB) 30 min after the beginning of the TsTx-induced SE was able to markedly reduce the frequency of the SRMSs and prevent the development of mossy fibres sprouting and hippocampal lesion.
As the parent compound, two of them, malonic acid dicyclopent-2-enyl ester (MRC2P119) and 2-oxo-3-oxa-bicyclo[3.1.0]hexane-1-carboxylic acid allyl ester (MRC2P57), were able to markedly increase the respiratory control ratio of isolated mitochondria.
Conservatives were alarmed by the continuous increase of the socialists' support during 1899 1916, which had climaxed in 1917 with their dominance in the Parliament and Senate, without the offsetting control of the Emperor and Russian administration; the socialists had to be halted before they were able to markedly alter the power structure of the country.
Altogether, we were able to markedly improve our previously reported protocol [9].
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