It has been suggested that α-MSH might be able to down-regulate MHC class I expression in melanoma cell lines [31].
LANA has been shown to be able to down-regulate the expression of the virally-encoded K1 gene by directly binding to its promoter [22].
It is tempting to speculate, that in addition to the well established up-regulation of Ih by cAMP and/or cGMP, neurons that express cGKII are also be able to down-regulate Ih via the NO/cGMP system by changing the ratio of phosphorylated versus non-phosphorylated HCN2 channels.
Thus, even if H. hepaticus may be able to down-regulate pro-inflammatory responses in epithelial cells, it is plausible that its interactions with other mucosal cell populations and/or other components of the host microflora may contribute to the inflammation normally associated with infection by this bacterium.
Thus, regulatory mechanisms induced by OVA feeding seemed to be able to down-regulate the BCII-specific immune responses in vitro and also shift it to a more Th2-like immune response.
Rutin was able to down regulate the levels of inflammatory markers like TNF-α, IL-6 and expressions of p38-MAPK, NFκB, i-NOS and COX-2.
WT Salmonella are able to down regulate the AMPs which is an important evasion strategy.
Tumors are able to down regulate adhesion molecules on the vascular endothelium.
None of the tested miRNAs was able to down regulate DLK1 to the extent observed in vivo.
The HDACi induced E-cadherin is a thus functional protein and is able to down regulate the wnt reporter activity in three out of four CLL specimens tested.
Consistently, Tet was able to down-regulate the activation of Akt and JNK as demonstrated by Western blotting assay.
