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Because the leaf phenotype of gns4 was not as stiff as those of the d11 1 and d11 2 mutants, we concluded that gns4 was likely to be a weak mutation of D11.
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This argument is one about the dynamics of allele frequency changes, where mutation seems to be a weaker force.
In lower organisms, the requirement for SIRT1 for DR longevity depends upon the experimental conditions, and in C. elegans, the SIRT1 ortholog sir-2.1 was required for lifespan extension by a weak mutation in eat-2, a genetic DR model, but not in other eat-2 experiments or DR methods that utilize bacterial food dilution (Mair et al., 2009; Kenyon, 2010; Burnett et al., 2011; Guarente, 2013).
Together, these data suggest that the molecular defect underlying the phenotypes associated with the CUB2/3 point mutations is a weak ability to bind Collagen IV. 10.7554/eLife.05508.012 Figure 5. Point mutations affect Collagen IV binding.
This mutation is a weak allele of mom-2/Wnt that affects a splice acceptor site at the last exon.
The classical reasoning of Fisher and Haldane (for references and explanation, see [ 35]) rejects variation-induced trends ("orthogenesis"), on the grounds that, because mutation rates are so small, mutation pressure is a weak force easily overcome by selection.
This is a weak penalty.
"It is a weak generation".
That's a weak point".
For such a model to apply, the rate of introduction of new mutations (2Nμ) must be small, i.e., the "pressure" of mutation is low, which explains why they sometimes are called "weak mutation" models [ 44].
Your bulb could be a unique mutation.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com