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Although, as in the current study, assessment of VD using a pan-endothelial cell antigen like CD31 or CD34 may be a weak marker to predict the likelihood to respond to anti-VEGF therapy, it is stressed that the usage of multi-tissue arrays (MTAs) for the vessel counting (like the method applied in the study by Jubb et al) should not be considered as equivalent to whole tissue sample evaluation.
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As previously reported, 46 telangiectasia may be a weaker marker of skin ageing in women due to the protective effect of oestrogens on skin microvasculature.
MMP-9 may be a weaker marker of CHD risk in healthy sub-groups because MMP-9 may be more important in de-stabilizing established plaques rather than having a directly atherogenic effect.
In summary, the limited available evidence suggests that NGAL is a weak marker of risk for renal function decline but might be a predictor of cardiac event in the setting of HF in patients with and without renal disease.
The latter is consistent with previous work showing that assessment of disease alone is a weak marker of health status in older individuals, even when indicators of disease severity are considered [ 62].
However, this would be a weak argument.
TasP provides an additional compelling argument for improving access to viral load monitoring as CD4 is a weak surrogate marker of viral suppression.
Yellow and/or green sputum has previously been found to be associated with antibiotic prescribing for RTI, despite it being a weak diagnostic marker for bacterial infection.
Survival analysis showed that the presence of K-Ras mutations diagnosed by direct sequencing are a weak prognostic marker of poorer outcome (median EFS 14 months vs 47 months, HR=1.57, CI 95%: 0.77 3.84, P=0.08).
His last, Dear Heather, was a weak effort, a marker of decline.
This is a weak penalty.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com