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The cAMP-mediated sweat rate test may be a useful endpoint for studies of new agents to increase the function of CFTR.
The esophageal or sublingual pCO2 gap may prove to be a useful endpoint for the resuscitation of trauma victims.
Since mortality is an end result of COPD, it can be a useful endpoint to define an impact on disease progression within a population receiving a study medication.
However, changes in GFR are sometimes not appreciated in the early stages of kidney disease, and in the case of slowly progressive kidney disease, this may not be a useful endpoint if follow-up is not long enough.
Our results suggest that given the high within-person variability of this novel biomarker, BNP is unlikely to be a useful endpoint in the context of a repeated-measures study of the acute health effects of ambient air pollution.
Tissue oxygen tension (ptO2) reflecting tissue oxygenation may be a useful endpoint; however, in the clinical setting ptO2 measurements subcutaneously (ptO2sc) and in muscle (ptO2im) are both used, although a comparative study has never been performed.
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Gene expression analysis by qPCR showed to be a useful EDA endpoint in zebrafish embryos and larvae when background information allows the selection of specific biomarker genes for the studied effect, as for estrogenicity.
These data argue that radial arm water maze testing of doubly transgenic mice may be a useful behavioral endpoint in evaluating the functional consequences of potential AD therapies, especially those designed to reduce Aβ load.
A cytoplasmic to nuclear relocalisation of p21 WAF 1/ CIP 1 could be a useful biological endpoint to analyse the potential efficacy of Herceptin.
We found that dCO2 may be a useful hemodynamic endpoint of resuscitation, while ScvO2 is not strictly a hemodynamic parameter, but rather an indicator of the balance between oxygen delivery and consumption [ 9].
Mortality or survival is preferred, but some measure of stage (or other measure of disease severity or treatment modality) is also a useful endpoint.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com