It is a uniform finding, for example, that elevating cytoplasmic cAMP is a potent stimulus for GLP-1 release, whereas the effectiveness of changing the nutrient concentrations is more variable.
Our observation that women tended to have a delayed arrival to hospital has been reported in a number of studies examining prehospital delay, although this is not a uniform finding.
Though several papers established that vasomotor (and associated) symptoms have a negative impact on women's productivity, capacity to work and work experience, this is not a uniform finding.
Results: Placental lesions were more common in diabetes/IGT and, although not being an uniform finding, in general associated with a higher vascular synthesis of thromboxane and/or lower prostacyclin/thromboxane synthesis ratio.
Cyclic sex hormone-dependent joint laxity has been implicated in the etiology of ACL injury in young women, although this is not a uniform finding [ 30, 49, 50].
A recent meta-analysis revealed that abnormal expression of these markers appears to be associated with poor 5-year survival, but this is not a uniform finding (Crijns et al, 2003).
Statin modulation of eNOS activity via this pathway has been demonstrated in cultured endothelial cells, although this is not a uniform finding [ 12, 13].
Recently, however, Bodega et al. reported that overexpression of FRG1 in muscle biopsies is not a uniform finding and may depend on the composition and age of the muscle biopsy, as FRG1 is only upregulated during an early state of differentiation into myotubes.
Furthermore, FRG1 overexpression in FSHD samples is not a uniform finding, [ 22, 23] and thus the contribution of the FRG1 gene to the FSHD phenotype needs further validation.
Despite the highly heterogeneous response to rapamycin seen in the panel of hepatic cell lines that we studied, a uniform finding was that rapamycin was effective in blocking mTOR signaling to S6 and 4E-BP1 in all cell lines.
