Nonetheless, each response reported in our study represents the first symptom that occurred at a single electrode contact, with minimum stimulation intensity, therefore, being a threshold response.
Thus, there may be a "threshold" ADRB response important for clinical protection, even if the precise biological phenomena it reflects are not clear.
Hence, while there may be some differences in absolute sensitivity, there will still be a threshold in the response.
To investigate whether there might be a threshold level in the exposure response relationship or a plateau at higher concentrations, we studied the shape of the association between PM10 and risk of death by using fractional polynomials.
We assumed that there is a threshold of responses in the fluorescent dye Ca2+ indicator and in an image acquiring system used to detect Ca2+ burst signals.
This work establishes a system for tight, tunable control of mammalian gene expression that can be used to explore the functional role of various genes as well as to determine whether a phenotype is the result of a threshold response to changes in gene expression.
There was strong evidence for a threshold response in species richness: non-linear models (broken-stick, exponential, inverse) exhibiting a sharp decline in species richness in landscapes with less than 10% habitat cover provided a better fit to the observed data than linear models.
In this experiment, the impact of a single variable (pulse duration) on the outcome variable current was assessed based on a threshold response.
A "threshold" response was also observed for the fungal qPCR analysis, but at a much lower concentration than was suggested by the diversity analysis, with all treatments exhibiting significantly lower SSU rRNA gene abundance than the unamended controls.
According to the law of mass action, the ability to display a threshold response should be dependent on the abundance of the M2 transactivator during the off-state (since it triggers the positive feed back loop) and therefore on the basal activity of the cA-promoter.
