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Previous data suggested that there may be a threshold dose required for biological effects and low intakes are unlikely to be bioactive (33).
Nevertheless, the available evidence suggests that there maybe be a threshold dose and duration required to see a benefit for lowering IS and PCS production [ 19].
Sheehan et al. (1999) found that there did not appear to be a threshold dose for estradiol-induced sex reversal of turtle embryos, the lowest dose tested (40 pg/g, ppt) showing 14% sex reversal in the turtle embryos.
Thus, a degree of uncertainty remains about the true quantitative effect of a given amount of alcohol on the risk of developing breast cancer, and in particular, whether there may be a threshold dose below which alcohol has no effect.
There needs to be a threshold dose for sickness to occur; There needs to be a threshold dose for sickness to occur; the magnitude of the dose is the single most determining factor for the health impact.
Similar(55)
But others say that estimating risk for doses near zero is nonsensical, and some believe there is a threshold dose, or limit below which there is no risk from exposure.
We therefore investigated further whether there was a threshold dose of dexamethasone that affected outcome within the entire trial population.
Thorn [ 31] concluded that inhalation of 30 40 μg LPS was a threshold dose for inducing clinical symptoms and lung function changes in healthy subjects via an inhalation challenge.
This study attempts to determine if there is a threshold dose exposure to TCE above which the developing heart is more likely to be affected.
This suggests that there is a threshold dose for growth stimulation by LA which, together with that in the diet, amounted to 3.8% of the total caloric intake.
Hence for policy makers, identification of the shape of the exposure response curve, and particularly whether there is a threshold dose, can be a key issue in decision making.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com