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There seems, however, to be a third pathogenic mechanism as well.
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Recently, repeat-associated non-ATG (RAN) translation has been detected in a subset of neurons in patient brains, raising the possibility that neurotoxicity of di-peptide repeats may be a third major pathogenic mechanism in these patients [ 7, 32].
A further patient was identified with a single heterozygous truncating mutation, c.128delT (p.Leu43*), however, a second pathogenic variant was not identified.
All three patients had a CNV that deleted the COH1 gene and a second pathogenic point mutation was subsequently identified on the other allele [ 37].
Regarding other cases in the current study (XF4 and 433), a second pathogenic allele could not be identified.
A sixth pathogenic strain, A14S, has been isolated from 1 Dutch (4 ) and 2 German patients with erythema migrans (5 ).
Steatotic livers are more sensitive to the induction of inflammation by a second pathogenic 'hit'hit
As a second pathogenic candadate, missense variants p.T2465S of EYS and p.V2228E of USH2A were detected and predicted to be pathogenic in patient 435 and 450, respectively.
Shigella spp. are the second pathogenic bacteria that cause intestinal diseases in China (Peng et al. 2002).
Trypanosoma (Trypanozoon) evansi (Steel 1885) Balbiani, 1888, is the first pathogenic mammalian trypanosome to be described in the world, in 1880, by Griffith Evans, in the blood of Indian equines and dromedaries [ 4].
"But that was a high pathogenic strain.
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