WESP induced a significant CYP2E1 activity, which suggests that WESP may be a substrate of CYP2E1.
Using these models, we identified MPA as substrate of MRP2 and MRP4, whereas its MPAG appeared to be a substrate of MRP2 only.
In this context, the ability of IE4 to be a substrate of this kinase was investigated.
We suggest that oxidized Nm23-H1 may be a substrate of TrxR1 or Trx (Figure 6A).
Therefore, Tex19.1 might be a substrate of ATE1-dependent arginylation and Ubr2-dependent ubiquitylation.
However, Rad17K197 is not conserved and based on structural arguments unlikely to be a substrate of Rad6/Rad18 [23].
Since LRRK2 interacts with ARHGEF7 and ARHGEF7 is known to be phosphorylated on several sites we also asked if ARHGEF7 might be a substrate of the kinase LRRK2.
Although ubiquitinated RIP is known to be a substrate of CYLD, the mechanism by which CYLD is recruited to RIP to deubiquitinate it, is not clear [14].
To explore the possibility that IL-10 could be a substrate of MMP-8, recombinant murine IL-10 was incubated with this enzyme.
These results taken together provide evidence that Bcl-w may be a substrate of Akt both in vitro and in intact cells (Figure 4B).
Though NF-κB has been shown to be a substrate of PKA, the downstream effects of it on translocation and transcription are still largely an enigma.
