Sentence examples for be a substantial obstacle from inspiring English sources

When the cascade feedback structure is considered, the zeros of the controller may be a substantial obstacle when designing a controller that has a good time response.

Law-abiding aliens might wish to return to their home country, for instance, but the strained relationship caused by the difficult repatriation talks might prove to be a substantial obstacle for these aliens as well.

The integration of c-Met and EGFR signaling in cancer cells indicates that treatment regimens designed to target both receptor pathways simultaneously could prove effective, though resistance to tyrosine kinase inhibitors continues to be a substantial obstacle.

This would appear to be a substantial obstacle for obtaining care in non-governmental facilities.

Whether this will be a substantial obstacle depends on ISPs and the amount of data OnLive streams.

Non-integration of TB and ART services is likely to be a substantial obstacle to timely initiation of ART.

However, immune rejection is a substantial obstacle to implantation of genetically engineered allogeneic or xenogeneic cells.

Third, effective dissemination is a substantial obstacle, and delivery is easily disrupted by environmental and meteorological conditions.

In the early stages of pregnancy, the court barred only laws that are a "substantial obstacle to a woman seeking an abortion".

"If they're denied or if the hospitals are dragging their feet, that's going to be more clear evidence that there's a substantial obstacle" to an abortion, clinic attorney Robert McDuff said.

The costs associated with compiling data on employee stock option portfolios is a substantial obstacle in investigating the impact of stock options on managerial incentives, accounting choice, financing decisions, and the valuation of equity.