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"There will be a substantial impact on operating profit from 2004 onwards," Cordiant said in a statement about the loss of the account, which included the Tia Maria, Ballantine's Scotch and Beefeater brands.
If the same is true for oral chemotherapy there will be a substantial impact on the provision of health care.
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"There's no evidence to suggest that there has been a substantial impact".
Upcoming local government budget cuts of 10% for 2015-16 are "likely to have further adverse implications for biodiversity conservation", warns the London Wildlife Trust, which says there has already been a "substantial impact" from previous cuts this parliament.
There is a substantial impact on education, career and earnings in the patients' perception.
In contrast, there was a substantial impact of C during the winter season.
There is a substantial impact of lipids on the coupling between the NBD and TMD.
Thus, there is a substantial impact of these diseases on public health.
Furthermore, there was a substantial impact of season/social environment on gene expression patterns, indicating the important role of external cues in shaping the molecular processes regulating behavior.
It has been also documented that there is a substantial impact of different recruitment strategies on the genetic structure of a Daphnia population among years with different weather conditions (in particular, warm vs. cold winters) [ 19].
We conclude that there is a substantial impact of the condensing material and ECoScreen2 was superior resulting in significantly higher levels of 8-iso PGF2α using the same EIA kit.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com