It is a substantial additional cost to Scottish families and taxpayers, because it is owed to the government by graduates.
Our simulation would not have been consistent with the SAVOR-TIMI 53 trial results, should there have been a substantial additional CV effect of DPP-4 inhibitors (beneficial or harmful) beyond those previously associated with HbA1c and weight changes.
In this context, the burden of HIV and TB is placing a substantial additional burden on the health system.
Current pharmacologic treatments are limited to either nonsteroidal antiinflammatory drugs (NSAIDs) or a limited number of anti tumor necrosis factor (anti-TNF) drugs (4); hence, there is a substantial need for additional treatment options in this disease area.
Even if the ranking of an activity suggests that it is providing no additional benefit at a substantial additional cost, stakeholders have a further opportunity to advocate for the preservation of the activity prior to making any final recommendations for disinvestment.
Most importantly, behavioral inhibition was also found to explain a substantial, additional proportion of the variance in SCARED-R scores in both the non-clinical and the clinically anxious group (12 and 24%% respectively).
Although it was possible to include only one – the most important – subgroup in the analysis, a substantial additional burden can be assumed from occupationally unexposed inhabitants and retired miners, which has not yet been quantified.
The effect of including this last additional sequence was a substantial increase in the Rd.HMM scores (roughly 6 times higher).
