This finding suggests that tetrasomy event is a subsequent step after gene deletion, which could justify the higher frequency of cells with two copies of chr17 and one TP53 copy and also the tendency of increased level of chr17 gain in tumors with higher extension.
A randomized controlled trial to investigate the ability of this model to screen in appropriate patients for targeted rehabilitation may be a subsequent natural step, and would provide opportunity to explore any concerns regarding its component parts.
If the program proves to be efficacious, a subsequent step could be a comparative effectiveness study with face-to-face treatment [ 61].
Surprisingly, a defect in the binding of PS1-hp MCM mutants to origins of DNA replication was not found by chromatin immunoprecipitation, suggesting a novel interpretation in which the defect is in a subsequent step of DNA strand separation by the MCM helicase.
If binding is of low affinity, the amount of protein that adheres to the beads in a pre-clearing step will be small, and there will be enough protein left to be precipitated in a subsequent step, using specific antibody to either the protein of interest or the putative binding partner.
As individual level ratings of social support and social capital are likely to be correlated, social capital was included at a subsequent step in the regression model to enhance our capacity to examine the benefits of community level support above those attributable to an individual's propensity for close social relationships.
If interesting CIPRAs are found, the associated data items can be analyzed in a subsequent step following the Ben Schneiderman visualization mantra of 'Overview first, zoom in and filter, details on demand' (Schneiderman, 1996).
Any negative branch lengths are corrected in a subsequent step as is the estimation of divergence times for nodes missing such values according to a pure-birth model based on relative clade sizes (see [ 122]).
The selection marker is integrated along with the edit and must be removed in a subsequent step.
In contrast, many recent publications have described efficient routes to obtain the monodispersed NPs, surfactants such as dextran or polyvinyl alcohol (PVA) can be added in the reaction media, or the particles can be coated in a subsequent step [17, 18].
