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Realistically, it will be a stepwise process, and we need careful thought on how to design the needed steps.
Tumor development is known to be a stepwise process involving dynamic changes that affect cellular integrity and cellular behavior.
Although sequential analyses starting from early glandular tissue infiltrates in pSS are not available, lymphocytic sialadenitis in pSS is generally thought to be a stepwise process [ 1- 4].
In summary, the observations presented here on the effect of LMB on hMdm2 indicate that the degradation of hMdm2 could be a stepwise process and therefore it can be limited in particular circumstances.
Since mutations at different sites of the pfdhfr and pfdhps genes might be a stepwise process, two mutations at codon 59 of pfdhfr and codon 540 of pfdhps can accurately predict the presence of this quintuple mutant [ 26].
Pathogenesis of gastric adenocarcinoma is believed to be a stepwise process resulting from aberrant oncogene activation and tumour suppressor gene (TSG) inactivations (Hanahan and Weinberg, 2000; Ponder, 2001; Ushijima and Sasako, 2004).
Similar(52)
Degradation of HA is a stepwise process that can occur via enzymatic or non-enzymatic reactions.
Cu2+xSe oxidation is a stepwise process leading to Cu2Se, CuSe, Se and finally Se(IV).
The evolutionary development towards the most specialised and successful forms (parasites of aculeate Hymenoptera [e.g., Xenidae+Stylopidae], ca. 46% of the species) is a stepwise process.
Our previous single-molecule fluorescence studies led to a model according to which branch migration is a stepwise process consisting of consecutive migration and folding steps.
Pluripotency enhancer selection is a stepwise process that also begins early in reprogramming through collaborative binding of OSK at sites with high OSK-motif density.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com