8 AI is not a single pathological entity.
It is now becoming clear that cHL, considered in the past to be a single disease entity with some pathological variants, comprises many different diseases characterized by distinct biologies, prognostic biomarker expression profiles, and response to therapies.
One impediment to treatment is that GBM is diagnosed as a single pathological entity, which cannot discriminate potential genetic drivers and molecular subtypes.
All were recruited from a single Pathological Gambling Unit in Spain (1709 strategic and 301 non-strategic gamblers).
When considering feedback parameters for PD, therefore, one must first establish whether the different aspects of the disease represent different manifestations of a single pathological system that could be potentially represented by a single biomarker or whether these different motor manifestations have different substrates and are therefore likely to be represented by separate biomarkers.
Our report emphasizes the importance of keeping IgG4-RD in the list of differential diagnosis for patients with panuveitis and especially for patients presenting with panuveitis and eye motility abnormalities as these combinations of clinical findings are difficult to explain by a single pathological entity otherwise.
As a result, therapies targeting a single pathological factor are often insufficient to achieve desired clinical outcomes, as has proven to be the case with anti-chemokine therapies.
Some contained a single pathological lesion that might be commonly encountered perhaps a palm-shaped shadow of a pneumonia, or the dull, opaque wall of fluid that had accumulated behind the lining of the lung.
Affixing a single, specific diagnostic label, whether at the clinical or pathological level, is generally more easily achieved in young patients in whom the brain succumbs to a single pathological process.
Pathological, biochemical and bioassay data all suggest that the epidemic form of cattle BSE is a single strain.
