A recent example is a single mutation in the C terminus of the cardiac Na channel, 1795insD.
"It is a single mutation; that was the beauty of it," he says.
It is a single mutation, or error, in EphB2 that turns the crest on.
Functional analysis of a rice grain incomplete filling 1 (GIF1) mutant has revealed that the cause is a single mutation in OsCIN2 (Wang et al. 2008).
"I suspect you need a complicated series of genetic changes to make a parasite that's not lethally unfit in the presence of these drugs," says White. "It would be unusual if this was a single mutation".
One consistent difference between the eastern and western birds is a single mutation in the cytochrome b gene of their mitochondrial DNA.
"Common" haplotypes are defined as being a single mutation or recombination event away from the ancestral haplotypes as such events are likely to have happened after a major population bottleneck.
Historically, proposed the concept of universal pleiotropy; that is, a single mutation can potentially affect all phenotypic traits.
All that was required to confer the protein's new function was a single mutation that revealed this molecular surface, apparently by changing the protein's conformational flexibility.
