Given that you are doing "long distance" research, record access can be a significant problem.
Nonetheless, Mr. Gray said that there could be a significant problem if Fannie Mae had a "cookie jar" reserve.
While investigators have traced where nearly all that money wound up, retrieving it will be a significant problem.
Reading that five year-old guidance, there is clearly no expectation that cancellation of housing benefit as a result of sanctions is, or will be, a significant problem.
Dr. Schultz said the codon he chose was rarely used by this bacterium, so this would not be a significant problem.
The use of bots "appears to be a significant problem", Collins wrote in the letter, while urging Bradley to more closely examine the ticket reselling industry.
Yet while doing this, he boldly declares himself to be a conservationist and that he considers climate change to be a "significant problem".
Compounds such as sulphur dioxide, benzene and carbon monoxide, that haven't been issues in western cities for decades, may be a significant problem in African cities.
"If Democrats are seen as obstructing that process, that could be a significant problem for them politically," said Christine Iverson, a spokeswoman for the Republican National Committee.
This is not a problem with either hot water or steam systems, but it can be a significant problem with forced-air systems.
"We looked at the regulation issue pretty aggressively and were not concerned that it is going to be a significant problem," Mr. Pecker said.
