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In this context, organ weights below the 5th or above the 95th centiles may indicate to the pathologist that there may be a significant pathological process.
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Early age lens cataract is a significant pathological signature of Danish dementia [8].
Thus, deficient adult neurogenesis is a significant pathological factor in AD and our findings suggest that therapies against AD will be more effective when supplemented with treatments that stimulate adult neurogenesis (such as exercise) or prevent impaired adult neurogenesis (such as anti-inflammatory drugs).
Hyperphosphorylated tau is a significant pathological feature of several dementias.
48 This is of particular interest since in the RA synovium angiogenesis is a significant pathological event responsible for its enlargement and invasive properties, and suggests an involvement of syndecan-2 in these mechanisms.
Thus, impaired neurogenesis is being recognized as a significant pathological feature of AD since it can further exacerbate the memory decline caused by neuronal loss.
Taking all these into consideration, there may be a significant association between NLR and pathological features and other known risk factors of RCC, but more clinical studies focusing on these relationships are still needed to help us better understand how NLR influences prognosis of patients with RCC.
Increased levels of proinflammatory cytokine are reported in serum and CSF from AD patients [37], [38] and neuroinflammation is recognized as a significant pathological event in AD [39], [40].
Neither ET-1 (P=0.403) nor ETBR (P=0.056) expression was a significant obstacle to pathological response.
Despite there is a significant correlation between pathological diagnosis and prognosis in canine patients with mammary tumour, there is still a need to improve treatment strategies [ 5, 6].
The finding of Clinical Perfectionism being a significant predictor of pathological worry adds to the literature by highlighting that a significant association exists between Clinical Perfectionism as measured by the CPQ and pathological worry.
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