There has to be a significant change in circumstances.
"Parental consent would be a significant change in the way the program functions," Sister Maire said.
"There needs to be a significant change in the levels of safety and security.
Mr. Remnick, 39, promises to be a significant change of pace.
The Orioles made few moves this winter, but a healthy Roberts could be a significant change.
"As we move into a multi channel world there's going to have to be a significant change in funding".
While turning to government full time will be a significant change, campaigning for office provided him with a useful transition.
Mr. Kalanick's leave will be a significant change for a company that was molded in his image.
Harman said: "Things like a cap on spending will be a significant change for the right reasons.
If all of those reforms are agreed it would be a significant change to the way Fifa is run.
"Hopefully, there won't be a significant change because Jared has been around enough that he has listened to everything," said Kevin Gilbride, the Giants' offensive coordinator.
