It would be a significant challenge".
The creation of a living dynamic circulation has proved to be a significant challenge.
Conducting research on massage therapy (MT) continues to be a significant challenge.
Ben van Beurden, the chief executive, said: "Lower oil prices continue to be a significant challenge across the business".
We also see, however, some challenges and a changing climate, weather variability, happen to be a significant challenge for producers.
Without a solid track record of success across multiple units, attracting the best franchisees will be a significant challenge.
Prediction of compound-induced hepatotoxicity in humans from in vitro data continues to be a significant challenge.
The characterization of hydraulic conductivity (K) variations in heterogeneous aquifers has proven to be a significant challenge.
"Our survey suggests that boosting both numbers and quality at the same time will be a significant challenge," said CIPD chief executive Peter Cheese.
wrote, "State legislative action on this matter will be a significant challenge and progress on this proposal is largely outside of the city's control".
Trying to stifle the two-time World Series defending champions, even if they are bobbing and weaving, can be a significant challenge.
