Three, NF-κB inhibition is shared by both drugs, supporting our hypothesis that this is a shared pathway of efficacy.
Because the pharynx is a shared pathway for food and air intake, pulmonary protection necessitates a high level of coordination between respiration and swallowing [ 13].
Substantial induction of these defence, cellular signalling and metabolism genes by PPV and other positive sense RNA viruses in infected leaf tissues suggests that there is a shared pathway modulating their expression.
Using such rich and balanced datasets, the same methodology can be generalized to discover synergistic triplets of genes using the definition of multivariate synergy [ 15], which will provide additional and more significant information helpful for pathway inference, as it will suggest that all three genes in the triplet will be members of a shared pathway.
Comparing the data from both mice exposed 51 common genes, many of which were involved in a shared pathway affecting the neuronal growth cone – cytoskeletal dynamics.
Thus, these data support the hypothesis that CLN6 and CLN3 mutations trigger distinct processes that converge on a shared pathway, which is responsible for proper subunit c protein turnover and neuronal cell survival.
Recently, it has been proposed that a generalized up-regulation of xenobiotic detoxification pathways may be a shared feature of long-lived mutants and a key mechanism of longevity assurance (McElwee et al., 2004; Shore et al., 2012; Steinbaugh et al., 2012).
As lead researcher Dr Jelena Ghadri says, there is a shared "emotional pathway" between sad and happy events: our bodies react physically to extreme emotions in a similarly damaging way.
Such a strong association might suggest that there is a shared pathophysiological pathway which is yet to be revealed.
Lacking this objective laboratory parameter, we could only assume that there is a shared pathophysiological pathway and that future studies in this field might reveal what it is.
