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In several growth-restricted models of long-life, we have shown evidence of increased proteostatic mechanisms, suggesting that proteostasis may be a shared characteristic of slowed aging.
The underlying reduced impulse control, a common characteristic of bingeing ED subtypes, might be a shared characteristic with the ADHD population [ 33].
This appears to be a shared characteristic for SF1 and SF2 helicases, and is further evidenced by the first binary complex of an SF2B helicase bound to a short ssDNA fragment, which is reported in the accompanying manuscript (Kuper et al, 2011).
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Willingness to heed that inner voice, with confidence and conviction, is a shared characteristic of successful people, he concluded.
The pectinate (comb-like) shape of the anterior teeth is a shared characteristic of the colugos and highly unusual among mammals.
In the tripartite model, negative affectivity is a shared characteristic between depression and anxiety.
Yen et al. reported that fun-seeking is a shared characteristic of IA and alcohol abuse [ 19].
This is a shared characteristic with ∼E8 mouse PGCs, hPGCs, and TCam-2 seminoma (Eckert et al., 2008).
Together, with our previously examined long-lived models, we suggest that the maintenance of proteostasis is a shared characteristic of slowed aging.
Collectively, our data further suggest proteostasis is a shared characteristic of slowed aging (Miller et al., 2012a, b; Drake et al., 2013, 2014) but may not necessarily be dependent on decreased mTORC1 signaling.
Overall, these data suggest estradiol-induced resistance is a shared characteristic across all three classes of PI3K pathway inhibitors tested, but there is marked heterogeneity in the inhibitory effect of estradiol across ER-positive breast cancer cell lines.
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