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This would be a severe setback for Internet users.
If confirmed, the diagnosis would be a severe setback to Jürgen Klopp, with his team challenging Chelsea and Manchester City at the top of the Premier League.
This was followed almost immediately be a severe setback to the plan for gathering up all the universities under the domination of the Lateran.
A unified chorus of dissent from the family foundations would be a severe setback for a merger that has been given a chilly reception on Wall Street since it was announced in early September.
If the treatment itself should prove to be the cause of his death it could be a severe setback for gene therapy, an experimental technique whose fulfillment has long fallen short of its high promise.
J. J. MacNab, a Maryland insurance analyst who tracks people who deny they owe taxes and has testified before Congress about the movement, said that an acquittal of Mr. Snipes would be a severe setback for the I.R.S. "He will get more press and attention than any other victory by the tax deniers, and the growth in new members will be exponential," she said.
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The case was a severe setback to the use of the secondary boycott by unions.
Their disappearance is a severe setback to Hassan Khan, a prisoner serving life for a 2007 robbery in West Wickham.
On the whole, I believe that the consequences of the crackdown have been a severe setback to the government.
The government has a majority of 63 and the result is a severe setback for Brown because it suggests that Labour discipline is breaking down.
Meanwhile, Kosovo's protectors would rejoice if Albanians and Serbs merely stopped killing each other; a wave of anti-Serb violence in March was a severe setback.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com