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Such computational complexity can be a severe issue particularly for real-time applications.
Lastly, sequence-nonspecific detection chemistries like SYBR Green give signal from all dsDNA products generated, including primer dimers and nonspecific amplification products, which can be a severe issue in complex samples.
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That is, they know it's a severe issue but it seems almost hopeless.
On the other hand, interference is a severe issue in multi-AP based scheme due to the simultaneous transmission from multiple APs to EUs, which often makes the resource allocation problem non-convex and thus hard to solve [5].
If stalking your ex on Facebook is a severe issue for you, consider taking some time off Facebook and limiting your weekly screen time.
However, when we checked the standard errors of these two variables in the logistic model, they were 0.01 for waist circumference and 0.02 for BMI, indicating that there was no substantial inflation, and suggesting that multicollinearity, if any, was not a severe issue in this model.
We found that the variance inflation factor was between 1 and 3 for each independent variable, suggesting that multicollinearity was not a severe issue [ 28].
However, the skewness and kurtosis values of all 18 items varied between −0.33 − 0.33 and −1.78 − 0.63 respectively which indicated that normality was not a severe issue.
— Anonymous A. Divorce would be a severe remedy to a tax issue, one that probably will not help your situation.
Electromigration is a severe reliability issue for polycrystalline aluminum-based interconnects.
Urban air pollution is a severe health issue in the country; the World Bank estimated in 2013 that 16 of the world's 20 most-polluted cities are located in China.
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