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Exact(26)
Losing glyphosate would be a serious setback.
This would be a serious setback for American oil interests and investment in that region.
Any problems with torcetrapib would be a serious setback for Pfizer, the world's largest drug company.
If the advance holds, it would be a serious setback for opponents of President Bashar al-Assad.
But it would be a serious setback were one of the more active of America's NATO allies to quit Afghanistan.
But tensions with Pakistan will remain a major foreign-policy distraction, and another war with Pakistan would be a serious setback for India's global ambitions.
Similar(32)
But it is a serious setback for judicial campaign reform.
The coup was a serious setback for democracy in Africa.
"But what has happened now is a serious setback".
President Obama's failure to make headway in talks with the Taliban is a serious setback.
For all that, Corbisiero's latest orthopaedic breakdown is a serious setback.
More suggestions(19)
be a serious impediment
be a grievous setback
be a serious inconvenience
be a serious downturn
be a serious drawback
be a serious failure
be a serious obstacle
be a serious disappointment
be a grave setback
be a serious defeat
be a major setback
be a serious backlash
be a serious player
be a serious health
be a serious risk
be a serious barrier
be a serious problem
be a serious threat
be a serious disease
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com