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It was predicted that only acyl-CoA syntethase may be a selective target for antimalarial treatment (selectivity score=1.97).
Furthermore, a critical molecule in cellular transformation as p21WAF has been proposed to be a selective target of Erk2 but not for ERK1 [50].
Many studies have shown that the tumour vasculature can be a selective target without affecting the existing vessels [ 19, 20].
As phenotypic plasticity itself may be a selective target, we explicitly test for variation among females in their average response (response in the average environment), and in their plasticity.
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This hypothesis might be consistent with the fact that AC7 is a selective target of alcohol (33,34), which increases its activity.
Since 5-AzaC interferes with MET1, there is a selective targeting of 5mCG, which in plants is associated with exonic DNA.
Rapidly reversible and regulated in large part by local nitric oxide (NO) status, this class of post-translational modification appears to be a selective process that targets specific cysteine and tyrosine residues to activate or restrict cellular events [1], [2], [3].
Although these markers provide an unbiased association with which to identify local adaptation, they also indicate that metabolism is often a selective target of local adaptation.
Recently, the DNA replication licensing pathway has been proposed as a selective target for anti-cancer therapy, since tumour cells appear to be deficient in a putative licensing checkpoint.
Mitochondria in tumor cells are structurally and functionally different from the organelles in non-transformed cells, and recently they are emerging as a selective target for tumor chemotherapy [ 29].
Hence, the scientific community should pay more attention to this immunological active location at the ocular surface as it might be a very selective target for some ingredients of the CL care systems.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com