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Bias in the codon usage can be a selection force for elongation speed [8], [9], translation accuracy [10] or to increase the fidelity of processes down-stream of translation [11] [13].
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Cancer itself has been a selection force that has shaped cancer suppression mechanisms that are as effective as they need to be, whatever the size of the organism.
While giving up a conception is inefficient, continuing to support a fetus who will likely succumb to infection is even more so, thus creating a selection force that could shape such a system.
During that transition, cancer suppression must have been a powerful selection force.
Sexual selection is a general selective force that has been intensively investigated in the past decades [see [ 1]].
It is peculiar to think that appendicitis could be the selection force that maintains the appendix!
But how can selection be a creative force?
It is to be expected that the promiscuous mating behaviour of chimpanzees is associated with a high level of sperm competition, where the need for an increased quantity and quality of sperm production would be a driving force in selection [3], [10], [11].
Darimont et al. (2009) postulated that harvest selection can be a consistent force, and we wanted to explore annual patterns of selection over many years on a wild population.
There is a good reason why the endpoints of the human cultural phylogeny may not reflect the action of natural selection, even though in principle cultural group selection could be a powerful force behind human cultural diversity.
Although it does shield people from other forces, culture itself seems to be a powerful force of natural selection.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com