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On the other hand, spermatozoa that have survived freezing and thawing may be a selected subpopulation, which has unusually stable membranes.
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Surgical decompression is the only available definite treatment for IAH, and numerous case series have been reported, but the effects of surgical decompression have not been reviewed in large series; patients who require decompression are frequently a selected subpopulation of the total study population.
Although some phenotypes showed greater aggressiveness and metastatic capability, only a selected subpopulation was able to metastatize in the multiple and heterogeneous tumor cell population.
Rather, T3 is only a negatively selected subpopulation.
Although this can greatly increase the sensitivity of the study to detect modulation by nutrition, care should be taken that the selected subpopulation is still sufficiently representative of the general population to allow meaningful extrapolation.
If this holds true, studies aiming at drug development based on genomic traits must be scrutinized rigorously as therapeutic recommendations may be valid for selected subpopulations only[ 64].
The global context of these studies is limited since most of these data are based on selected subpopulations or retrospective case series with different outcomes and heterogeneous diagnostic criteria.
The value of probiotics for treatment in IBS was debated for long time; however, several recent systematic reviews, guidelines and meta-analyses confirmed, despite all gaps and methodological limitations, that selected probiotics are effective in selected subpopulations of patients with IBS [ 205- 209].
The pharmacokinetics of enclomiphene citrate were assessed in a select subpopulation.
However, interventions considered failures may in actuality be highly effective in selected subpopulations.
The percentage of CSCs in the cycling hypoxia selected subpopulation was analyzed based on the CD44, CD24, ESA, and E-cadherin expression by three-color flow cytometry.
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