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A patient who is a non-responder to a triptan during the first attack may then be a responder (grade A methodology).
On the basis of this finding they have developed a genetic test to predict who is likely to be a responder, and who is not.
For early recurrence the following criteria had to be fulfilled: patient considered to be a responder on Day 7, worsening of symptoms in the follow-up period (sum score ≥ 6) and a microbiological test result indicating ≥ 104 colony forming units (CFU/ml).
A child was considered to be a responder if, upon CS antigen whole blood stimulation, the frequency of CS-specific cytokine expressing T cells was greater than or equal to the geometric mean + 3 standard deviations of cytokine expressing T cells in unstimulated samples.
When this function takes values above zero, then the respected depressed patient is predicted to be a responder with a 89.47% chance of success.
For trough FEV1, a patient with a change from baseline of at least 100 mL was considered to be a responder [ 25].
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She was a "responder".
"So once we've tested a child, we could give him a dose, wait 90 minutes, and if he's a responder, his performance will improve enormously.
The primary efficacy parameter was a responder analysis at study end.
Total Hospital Anxiety and Depression Scale (HADS) score at baseline was predictors (p < 0.005) for being a responder after 4 years.
The probability of being a responder to onabotA was 28 times higher with a CGRP level above the threshold of 72 pg/ml.
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