Our study suggests that PFS at 2 years could be a reliable surrogate endpoint for 5-year survival rate in LA-NSCLC patients treated with concurrent CRT.
These findings underline the uncertainty surrounding the optimum method of assessment of response in biomarker studies and raise concerns that one (or perhaps both) of the classifications of response used in this study may not be a reliable surrogate endpoint.
Analysis of the intrafollicular thyroxine-content of zebrafish larvae exposed to potential disruptors has proved to be a reliable, physiologically relevant endpoint to estimate effects of chemicals on the mammalian thyroid gland.
Although wear, osteolysis, and ARMD may predispose to dislocations, we believe that revision for dislocation is still a reliable endpoint for registry studies.
That can be a reliable vehicle.
Our goal was to develop a reliable endpoint genotyping method where the fluorescent intensity of a single-hybridization probe would reflect genome composition.
In some situations, OS is no longer a reliable endpoint, e.g. in advanced colorectal cancer treated in the first line, mainly because of the increasing availability of effective agents in the subsequent lines [ 33].
Fortunately, the results showed a consistent reduction of MDA with hydrogen dose, which demonstrates it is a reliable and stable endpoint in aspirin-HCl injury model.
"We do not believe that the proposed validation study will result in a technique that could be routinely used in a test guideline and would provide a reliable endpoint for regulatory risk assessment," she wrote to the international standards-setting group.
