Sentence examples for be a relevant pathway from inspiring English sources
EphA4/c-Abl signaling could hence be a relevant pathway involved in the early cognitive decline observed in AD patients [ 21].
Since the activation of the Th2 cytokines seems to be a relevant pathway in the pathogenesis of SLE, the gestation-induced Th2 polarization of immune response might theoretically contribute to a disease flare during pregnancy in SLE women [ 1, 11].
Although there is mounting evidence that this may be a relevant pathway in Drosophila metamorphosis [ 5], the role of autophagy as a positive mediator of cell death is unclear and not well understood in mammalian systems.
Although conceivable, it needs to be explored as to whether Notch3 signalling per se might be a relevant pathway in the development of cerebral small vessel disease with advancing age.
We tested the hypothesis that JNK might be a relevant pathway following TBI in humans and in a model of cerebral contusion, and evaluated the neurobehavioral and histological effects of its pharmacological inhibition by the administration of DJNKI-1, a peptide that selectively prevents the binding between JNK and its substrates.
JNK signaling is a relevant pathway for keratinocyte differentiation and it is negatively regulated by CYLD.
In view of the importance of iron deficiency in hypoxia inducible factor-1alpha (HIF-1α) stabilization and the role of HIF-1α in Notch signaling, [ 29, 30] iron deficiency-mediated HIF-1α is a relevant pathway to be investigated in the future.
In these cells, EGF stimulation has induced the expression of CXCL8, indicating that activation of RTKs is a relevant pathway for induction of CXCL8, which may account for Ras hyper-activation in breast tumor cells that do not carry mutated Ras.
The observation that high levels of the y-HBCDD isomer, which dominates commercial mixtures of this flame retardant [47, 48], can be detected in fish in some European waters [49], indicates that direct exposure to technical HBCDD present in the polymer matrix can also be a relevant exposure pathway for fish, as well as the wider environmental exposure to the more stable α-HBCDD.
The fibroblast growth factor receptor (FGFR) signaling pathways may be a relevant target in MPM.
