Sentence examples for be a relevant modulator from inspiring English sources

According to these results, we conclude that the absence of MMP-8 has an antifibrotic effect by increasing IL-10 and propose that this metalloprotease could be a relevant modulator of IL-10 metabolism in vivo.

These findings open the possibility that IL-10 could be responsible for the benefits seen in terms of fibrosis in knockout mice and suggests that MMP-8 can be a relevant modulator of IL-10 function.

The endogenous cannabinoid system is a relevant modulator of dopaminergic synapses in dorsal striatum.

Arginase, induced in response to inflammatory stimuli in a variety of cell types [7] [9], consists of two isozymes (types I and II), and there is increasing evidence that arginase is a biologically relevant modulator of vascular structure and function.

Adiponectin is a biologically relevant modulator of vascular remodeling linking obesity and vascular disease.

Finally, we review the literature on the role of ATP in inflammation and speculate that the ATP-induced allosteric activation of 5-LO Xin vitro is a potentially relevant modulator of inflammation in vivo.

35,38,39 Support for CB2R being a physiologically relevant modulator of macrophage inflammation in vivo came from analysis of endocannabinoid levels in human atherosclerotic lesions in carotid arteries and reduced MMP-2 secretion by human inflammatory cells treated with the CB2R-selective agonist JWH-133.

Protein tyrosine phosphatase 1B (PTP1B) is a ubiquitously expressed phosphatase that has emerged as a relevant modulator of signaling pathways initiated by the activation of the tyrosine kinase receptor superfamily.

The endocannabinoid system (ECS) is a relevant candidate to participate in the etiopathology of HD as it is a key modulator of brain function, especially in areas primarily affected by HD dysfunction such as the striatum.

This is a relevant issue, as osteoblastic cells, in addition to being responsible for the bone formation events, are essential modulators of the osteoclastogenesis, through the production of a variety of molecules [ 22].

Here's a relevant talk:.