In fact, according to the most recently released consensus document on HAE treatment, antifibrinolytics are not considered as a relevant agent.
At design of this study, advanced age (>70) was a relevant selection criterion for single agent vs. platinum doublet chemotherapy, as addressed in national U.S. guidelines [ 48].
In an area of controversy, the first two cases provide further evidence that in selected patients, if ascertained to be the sole agent, HSV-1 is a relevant pathogen of pneumonitis that is amenable to treatment.
Apart from being the relevant agent for metal sulfides dissolution, iron represents also an indicator for leaching efficiency, since it represents itself a product of most of the metal sulfide dissolutions (pyrite, chalcopyrite, and arsenopyrite).
Other exposures that have been proposed as relevant agents but which were not considered here because of insufficient evidence include vinyl chloride, formaldehyde, radiation and electromagnetic fields (mobile phones), and work in the rubber industry, fire-fighting and laboratory scientists (Wrensch et al, 2002; Preston-Martin et al, 2006).
In controlled studies an antidepressant would be relevant to that agent and only that agent, rendering such studies worthless.
The mTORi alone or combined with the AKTi, at the clinically relevant doses selected, was a most effective agent on a background of E2 or ED.
Austin notes that some of the responses to the autonomy objection may be relevant, as an agent must choose whichever religion and morality they judge to be correct.
As the primary end point was feasibility, treatment was not to be delayed due to toxicity, rather the relevant agent was omitted until the adverse event had resolved, followed by subsequent dose modification.
Most studies of c-Src oxidation have revealed H2O2 to be the relevant oxidizing agent.
