Knockouts of various alternative pathway components have demonstrated roles in maturation of B cells [23] and induction of TH17 cells [24], as well as differentiation of osteoclasts [8], suggesting that this pathway might be a relatively specific target for autoimmune diseases, especially those associated with bone loss.
The ability to convert resveratrol to piceatannol has been surmised to be a relatively specific property of CYP1B1 (Potter et al, 2002b).
From an analysis of KO mice, SOCS2 has been shown to be a relatively specific negative regulator of GH STAT5 [ 13, 14].
This white matter profile was identified after taking disease severity into account; moreover, a similar emphasis of white matter tract alterations was identified when the bvFTD group was compared with the AD group, suggesting that involvement of these tracts may be a relatively specific index of pathologies in the bvFTD spectrum.
Upregulation and shedding of sEng into the peripheral circulation due to endothelial activation during dengue virus infection may account for this observation, and may be a relatively specific indicator of dengue infection, since levels were not elevated in leptospirosis compared to healthy controls.
The predictive significance of cognitive ability may depend on its development: while stably low cognitive ability predicts a wide range of adult mental disorders [ 14, 83, 84, 86], a progressive decline below one's projected trajectory may be a relatively specific antecedent to schizophrenia [ 85, 86].
Although 8CPT-2'-OMe-cAMP is a relatively specific activator of Epac proteins, it is a weak and less effective activator of PKA [28], [30], [35].
2-Deoxy-D-glucose (2-DG) is a relatively specific blocker for glycolysis because it cannot be further metabolized by hexokinase.
CFTRinh172 is a relatively specific inhibitor of this chloride channel that may interact with the sixth transmembrane helix in CFTR, probably preventing pore opening [16].
The possibility that the increased sensitivity to LatB might be secondary effect can not be excluded, although LatB is a relatively specific actin depolymerization drug which acts by forming a high affinity complex with monomeric actin.
