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SQSTM1 may be a recurrent target of chromosomal aberration.
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School aides have been a recurrent target of layoffs.
But Viasna is a recurrent target for police harassment and has been raided five times in the past year.
He has not let go of the Obamacare repeal or the wall, he has pushed various versions of a travel ban to keep Muslims from entering this country, and "Crooked Hillary" is a recurrent target of his Twitter storms.
The Mixed Lineage Leukaemia (MLL) gene (also called HRX, HTRX or ALL-1) on chromosome band 11q23 is a recurrent target of reciprocal translocation in human acute leukaemias.
DCLK1, a newly identified marker of transformed stem cells in the gut [ 49], was also mutated in 8.3 % of cases (Table 2, Fig. 2), and is a recurrent target for mutation in neoplasms of the stomach [ 25], appendix [ 37] and skin [ 50].
Furthermore, the ALK locus is also a recurrent target of copy number gain or amplification in sporadic NB [ 59- 63, 126].
These studies indicate that the chromatin regulatory machinery is a recurrent mutational target in a broad range of cancer types highlighting the importance of correct regulation of chromatin remodeling in the homeostasis of normal tissues.
WIF1 is a potent extracellular Wnt antagonist, a recurrent target for genomic rearrangement in salivary gland PA, and an attractive target for cancer therapy.
The most frequent SCNA observed in Group 4 (33/317; 10.4%) is a recurrent region of single copy gain on chr5q23.2 targeting a single gene, SNCAIP (synuclein, alpha interacting protein) (Fig. 4a and Supplementary Fig. 24).
Primary skin fibroblasts are an attractive target tissue for retroviral-mediated gene therapy; however, transient expression of therapeutic genes has been a recurrent problem in several rodent models.
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