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The test material has to be a realistic sample of the actual data that belongs to the target application scenario.
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Since all patients registered in the programme with a baseline fitness test were included, the participants represent a realistic sample of the population of people who are likely to access cardiac rehabilitation.
If it is the case that both common and rare variants contribute to ADHD risk, but genome-wide significant association cannot be a realistic goal with currently sized samples, we might expect to see a convergence of subthreshold signals from both types of variants influencing common biological risk pathways.
That would be a realistic ambition and a realistic aim.
This may not be a realistic equivalence.
This may not be a realistic assumption.
Such an exchange rate might not be a realistic value.
It needs to be a "realistic" commitment.
The synthesis tool, implemented in AIMMS®, is applied to a realistic sample problem, showing profit optimisation by varying the distribution of NG to syngas generation units with different efficiencies.
This effect size was chosen because it yielded a realistic sample size.
This also means that the calculation of Bayes factor before a realistic sample size has been reached will also be relatively unreliable, because the observed effect size used to calculate Bayes factor might be erroneous (Additional file 1: Table S1).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com